Aporphine alkaloids from Guatteria spp. with leishmanicidal activity.
نویسندگان
چکیده
Fractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1-4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD 50 = 3 microM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.
منابع مشابه
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عنوان ژورنال:
- Planta medica
دوره 69 7 شماره
صفحات -
تاریخ انتشار 2003